Director Mysskin announced a sequel to his super hit horror drama 'Pisasu' last year with Andrea Jeremiah in the lead role. The film is produced by T.Muruganandham of Rockfort Entertainment and has a musical score by Karthik Raja (Legendary composer Ilayaraja's son).

The principal photography of the film began in December 2020. Mysskin has traveled deep into the forest that has no roads to shoot some major portions of 'Pisasu 2'. Then, the shooting was stopped due to the lockdown. The team resumed the shooting in July 2021 and finished in August 2021.

Vijay Sethupathi essays a brief cameo in Pisasu 2 while Poorna, Santhosh Prathap, Namita Krishnamurthy and Ajmal play pivotal roles. The film is primarily shot in Tamil and will be dubbed and released in three languages -Telugu, Malayalam, and Kannada. The movie's release date will be soon revealed by the makers.