Priyamani made her debut in to the Telugu Industry with the film ‘Evare Athagadu’ which also happens to be a first venture for Vallabh, son of KS Rama Rao. Directed by Bhanu Shankar, the movie was produced by KS Rama Rao.

The film did not reap the expected success for her, and consequently she went back to the Tamil Industry. After a gap, she started her second innings as heroine with 'Pellaina Kothalo' in the direction of Madan. Followed by 'Yama Donga' that got her the much needed recognition, offers started pouring in from Tollywood. Shewent on to work as heroine with Kalyan Ram in the film 'Hare Ram'.

Presently, she is working for a film opposite Balakrishna who plays the protagonist. The movie is made in the directorial venture of Mahadev, an associate of Rajamouli and is produced by Sivalenka Krishnaprasad on Vaishnavi Devi Arts banner.

Adding to this, she is sharing screen space in a film once again with Balakrishna playing the lead. This flick is made in the direction of N.Shankar which is being produced by Kalyan Ram on Nandamuri TarakaRama Rao arts banner.

Priyamani is working in two parallel films along with Balakrishna at the same time. Further, she is the only heroine to be credited for acting with all the present heroes of Nandamuri family.